At the risk of mortally offending the Italians and the Scots, there's only one truly competitive match this weekend, and that's England against Wales at Twickenham.
Last season's champions are wracked by injuries, and with England showing some promising signs of semi-recovery during the Autumn, this should be a comfortable victory for the home team. However, I suspect that despite having about 70% of possession, England's backs will somehow conspire to make it look difficult.
Prediction : England by 9.
Key man : Lewis Moody, Has only played 40 minutes of rugby in the last two months, will be targeted by the Welsh, and I still think he's suspect as an international open-side - he's a natural number six for me. If he can keep the ball away from dangerous linkman Martyn Williams, it'll make England's job much easier. If he loses his discipline, Big Lol may make his comeback earlier than expected.